Review:Studi Tumbuhan Sebagai Antitukak Pada Bagian D
Article Sidebar
Main Article Content
Abstract
Tukak peptik merupakan kumpulan penyakit yang ditandai dengan adanya gangguan pada mukosa esofagus, lambung atau usus halus . Penyebab utama dari tukak peptik yaitu meningkatnya sekresi asam dan adanya gangguan keseimbangan yang disebabkan oleh agresi resistensi mukosa. Namun, obat-obatan tersebut memiliki efek samping yang cukup berat. Tanaman dapat digunakan sebagai alternatif pengobatan antitukak. Artikel ini bertujuan untuk memberikan informasi mengenai berbagai tanaman yang memiliki aktivitas antitukak yang sudah diuji kepada model hewan. Beberapa tanaman tersebut di antaranya yaitu Averrhoa blimbi L., Gynura pseudochina L., , Phyllantus niruri L., Andrographis paniculata, dan Olea europaea. Berdasarkan aktivitas yang dimiliki, tanaman yang memiliki kandungan kimia alkaloid, terpen, terpenoid, flavonoid, saponin, asam fenolik dan tanin terbukti memiliki efek sebagai antitukak dengan berbagai variasi dosis efektif.
Article Details
References
D Alrashdi AS, Salama SM, Alkiyumi SS, Abdulla MA, Hadi AHA, Abdelwahab SI, et al. Mechanisms of Gastroprotective Effects of Ethanolic Leaf Extract of Jasminum sambac against HCl / Ethanol-Induced Gastric Mucosal Injury in Rats. Evidence-Based Complement Altermative Med. 2012;2012
Althaiban MA. Antiulcer Potential of Olive Leaves Extract in Gastric Ulcer Induced by Indomethacin in Male Rats: Antioxidant and Anti-Inflammatory Effects. Pharmacophore. 2018;9(6):57– 64.
Bhoumik D, Masresha B, Mallik A. Antiulcer Properties of Herbal Drugs : A Review. Int J Biomed Res. 2017;8(3):116–24.
Borra SK, Lagisetty RK, Mallela GR. Anti-ulcer effect of Aloe vera in non-steroidal antiinflammatory drug induced peptic ulcers in rats. African J Pharm Pharmacol. 2011;5(16):1867–71.
Jalilzadeh-amin G, Najarnezhad V, Anassori E. Antiulcer Properties of Glycyrrhiza Glabra L . Extract on Experimental Models of Gastric Ulcer in Mice. Iran J Pharm Res. 2015;14:1163–70.
Lastra CA, Martin MJ, Motilva V. Antiulcer and Gastroprotective Effects of Quercetin: A Gross and Histologic Study. Pharmacology. 1994;48:56–62.
Majee C, Pradesh U. Medicinal Plants with AntiUlcer and Hepatoprotective Activity: A Review. Int J Pharm Res Sci Res. 2019;10(1):1–11.
Mostofa R, Ahmed S, Begum MM, Rahman S, Begum T, Ahmed SU, et al. Evaluation of anti-inflammatory and gastric antiulcer activity of Phyllanthus niruri L . ( Euphorbiaceae ) leaves in experimental rats. BMC Complement Altern Med. 2017;17:1–10.
Pal A, Chinnaiyan SK, Mallik A, Bhattacharjee C. Anti ulcer activity of leaves of Averrhoa carambola Linn. Int J Pharmacol Res. 2019;9(5):1–6.
Palayyan M, Jeyabalan S. Antiulcer Activity of Morinda Citrifolia Linn Fruit Extract. J Sci Res. 2009;1(2):345–52.
Panneerselvam S, Arumugam G. A biochemical study on the gastroprotective effect of hydroalcoholic extract of Andrographis paniculata in rats. J Pharmacol. 2011;43(4):402–8.
Razik A, Farrag H, Abdallah HMI, Khattab AR, Elshamy AI, Hegazy MF. Phytomedicine Antiulcer activity of Cyperus alternifolius in relation to its UPLC-MS metabolite fingerprint : A mechanistic study. Phytomedicine [Internet]. 2019;62(May):152970. Available from: https://doi.org/10.1016/j.phymed.2019.1 52970.
Saito H, Lee Y-M, Takagi K, Shibata S, Shoji J, Kondo N. Pharmacological Studies of Panacis Japocini Rhizoma. Chem Pharm Bull. 1988;25(5):1017–25.
Samara K, Mota DL, Eduardo G, Dias N, Emili M, Pinto F, et al. Flavonoids with Gastroprotective Activity. Molecules. 2009;14:979–1012.
Srinivas TL, Lakshmi SM, Shama SN, Reddy GK. Medicinal Plants as Anti-Ulcer Agents. J Pharmacogn Phytochem. 2013;2(4):91–7.
Sukandar EY, Safitri D, Pamungkas AD. Uji Aktivitas Antitukak Ekstrak Etanol Daun Belimbing Wuluh ( Averrhoa bilimbi L .) dan Daun Dewa ( Gynura pseudochina ( L .) DC .) pada Tikus Wistar Betina yang Diinduksi Etanol. Acta Pharm Indones. 2014;39(3):63–8.
Tytgat GNJ. Etiopathogenetic Principles and Peptic. Dig Dis. 2011;454–8.
Waldum HL, Gustafsson B, Fossmark R. Antiulcer Drugs and Gastric Cancer. Dig Dis Sci. 2005;50:39–44.