Review: Aktivitas Antiinflamasi Ekstrak Etanol Tanaman Patah Tulang (Euphorbia Tirucalli L.)
DOI:
https://doi.org/10.32670/ht.v1i7.1720Keywords:
Anti-inflammatory, Euphorbia tirucalli.Abstract
Fracture plant branch extract has potential as a medicinal plant which has been detected to have secondary metabolite compounds that can provide antiinflammatory effects. The compounds contained in the methanol extract of fracture branches were flavonoids, tannins and saponins, while the chloroform extract was only detected positive for alkaloids. The purpose of this study was to examine the anti-inflammatory activity of the ethanol extract of the fracture plant against edema caused by carrageenan in rats' feet. In this review article, we will provide information and discuss the anti-inflammatory activity of fracture plants along with the suspected class of compounds that play a role in inhibiting this inflammation).
References
Agustina, R., Indrawati, D. T., & Masruhin, M. A. (2015). Aktivitas Ekstrak Daun Salam
(Eugenia poyantha) Sebagai Antiinflamsi Pada Tikus Putih (Rattus norvegicus). J.
Trop. Pharm. Chem, 3(2), 120-123.
Audina, M., Yuliet & Khaerati, L. (2018). Efektivitas Antiinflamasi Ekstrak Etanol Daun
Sumambu (Hyptis capitata Jacq) Pada Tikus Putih Jantan (Rattus norvegicus L.)
yang Diinduksi Dengan Karagenan. Biocelebes, 12(2), 17-23.
Baud, G. S., Sangi, M. S., Koleangan, H. S. J. (2014). Analisis Senyawa Metbolit
Sekunder & Uji Toksisitas Ekstrak Etanol Batang Tanaman Patah Tulang
(Euphorbia tirucalli L.) dengan Metode Brine Shrimp Lethality Test (BSLT).
Jurnal Ilmiah Sains, 14(2), 106-112.
Chowdary, K. P. R., Mohapatra, P., & Murali Krishna, M. N. (2006). Evaluation of
Olibanum and its Resin as Rate Controlling Matrix for Controlled Release of
Diclofenac. Indian J. Pharmacol. 68(4), 497-500.
Dalimartha, S. (2006). Atlas Tumbuhan Obat Indonesia Jilid 4. Puspa Swara.
Fitriyani, A., Lina, W., Siti, M., Nuri. (2011). Uji Antiinflamasi Ekstrak Metanol Daun
Sirih Merah (Piper crocatum Ruiz & Pav) Pada Tikus Putih. Majalah Obat
Tradisional, 16(1), 34-42.
Garaika, C. S. H., Sangi, M., Koleangan, H. S. J. (2020). Uji Aktivitas Antiinflamasi
Ekstrak Etanol Tanaman Patah Tulang (Euphorbia tirucalli L.). Jurnal MIPA, 9(2),
-63.
Hernani, M. Y., Mufrod, S. (2012). Formulasi Salep Ekstrak Air Tokek (Gekko gecko
L.) untuk Penyembuhan Luka. Majalah Farmaseutik, 8(1), 120-126.
Hidayati, N. A., Listyawati, S & Setyawan, A. D. (2005). Kandungan Kimia & Uji Anti
Inflamasi Ekstrak Etanol Lantana camara L. Pada Tikus Putih (Rattus novergicus
L.) Jantan. Jurnal Bioteknologi, 5 (1).
Indonesian Reumatology Association. (2014). Rekomendasi IRA untuk Diagnosis &
Penatalaksanaan Osteoartritis. 16-24.
Julianus, K., Diah, I., Supratman, T., Harwiyadin, K., Yermias, K., Syamsir, S., &
Moody, C. K. (2011). Tumbuhan Obat Tradisional Di Sulawesi Utara Jilid 1. Balai
Penelitian Kehutanan Manado.
Katzung, B. G. (2002). Farmakologi Dasar & Klinik. Penerbit Salemba.
Khanna, N. & Sharma, S. B. (2001). Antiinflammatory and Analgesic Effect of Herbal
Preparation: Septilin, Indian J. Med. Sci, 55(4), 195-202.
Kim, H. P., Son, K. H., Chang, H. W., Kang, S. S. (2004). Anti-inflammatory plant
flavonoids and cellular action mechanisms. J. Phamacol. Sci, 96, 229-245.
Landefeld, K., Gonzales, H. & Sander, G. (2016). Hypertensive Crisis: The Causative
Effects of Nonsteroidal Anti-Inflamatory Drugs. Journal of Clinical Case Reposrts,
(7), 1-3.
Lucas, S. (2016). The Pharmacology of Indomethacin. Headeache, 56(2), 436-446.
Manjunatha, K. M., Ramana, M. V., & Satyanarayana, D. (2007). Design and Evaluation
of Diclofenac Sodium Controlled Drug Delivery Systems. Indian J. Pharmacol,
(3), 384-389.
Mitsui, T. (1997). New Cosmetics Science. Elsivier.
Morshed, G. (2011). Evaluation of Analgesic and AntiInflammatory Effect of Terminalia
Arjuna Ethanol Extract. IJPSR, 2(10), 2577-2585.
Mwine, J. T. & Dame, P. V. (2011). Why di Euphorbiaceae Tick as Medicinal Plants? A
Review of Euphorbiaceae Family and Its Medicinal Features. Journal of Medicinal
Plants Research, 5(5), 652-662.
Palit, P., Dhrubojyoti, M., Poulami, M., Shadab, Md., Nahid, A., Shubhadeep, R., Asad,
Md., Subhash, C. M. (2017). Attenuation of nociceptive pain and inflammatory
disorders by total steroid and terpenoid fraction of Euphorbia tirucalli Linn root in
experimental in vitro and in vivo model. Inflammopharmacology, 26(5), 235–250.
Ratnawati, G., Kurniasih, K., Amanu, S. (2019). Effect of Patah Tulang Latex (Euphorbia
tirucalli L.) on Wound Healing in Wistar Rat. Indonesian Journal of
Pharmaceutical Science and Technology, 6(3), 104-111.
Siswandono & Soekarji. (1995). Ilmu Patologi. Jakarta: Kedokteran EGC.
Soesatyo, M. H. N. E. (2002). Proses Inflamasi, Penggunaan Analgetik & Antiinflamasi
Non-Steroid Secara Rasional, Bagian Farmakologi & Toksikologi, Fakultas
Kedokteran Universitas Gadjah Mada.
Sukmawati, Y., & Har&i, R. (2015). Uji Aktivitas Anti Inflamasi Ekstrak Etanol Daun
Pisang Ambon (Musa pradisiaca L.) Terhadap Tikus Putih (Rattus orvegicus L.)
yang diinduksi Keragenan. Gelanika, 1(2), 126-132.
Thakare, M., & Singh, K. K. (2006). Preparation and Evaluation of Diclofenac sodium
Controlled Release Tablets Using Spray-drying Technology in Aqueous System.
Indian J. Pharmacol, 68(4), 530-532.
Toana, M. H. & Nasir, B. (2010). Studi Bioaktivitas & Isolasi Senyawa Bioaktif
Tumbuhan Euphorbia tirucalli L. (Euphorbiaceae) sebagai Insektisida Botani
Alternatif. Jurnal Agroland, 17(1), 47-55.
Vogel, H. G. (2002). Drug Discovery & Evaluation: Pharmalogical Assays 2
nd Edition.
Springer.
Voight, R. (1994). Buku Pelajaran Tehknologi Farmasi. Gajah Mada University Press.
Wahid, A. R. & Safwan. (2020). Skrining Fitokimia Senyawa Metabolit Sekunder
Terhadap Ekstrak Tanaman Ranting Patah Tulang (Euphorbia tirucalli L.). Jurnal
Ilmu Kefarmasian, 1(1), 24-27.
Wal, A., Wal, P., Gupta, N., Vishonoi, G., & Srivastava, R. S. (2013). Medicinal Value
of Euphorbia tirucalli. International Journal of Pharmaceutical and Biological
Archives, 4(1), 31-40.
Yuniarni, U., Siti, H., Winda, O., & Ratu, C. (2015). Aktivitas Antiinflamasi Ekstrak
Etanol Buah & Daun Asam Jawa (Tamarindus Indica) Serta Kombinasinya Pada
Tikus Jantan Galur Wistar. Prossiding SnaPP, 1(1), 83-88.