Aktivitas analgesik tanaman gedi (Abelmoschus manihot L.) pada mencit (Mus musculus)
DOI:
https://doi.org/10.32670/ht.v2i3.1444Keywords:
Analgesics, Gedi Plants, Gedi Leaf, Mice, ExtractsAbstract
Gedi plant (Abelmoschus manihot L. Medik) is a tropical plant of the Malvaceae family
which has been known in North Sulawesi as a vegetable plant. Gedi plants have various
medicinal benefits, such as antidiabetic, antimicrobial, anticancer, analgesic, antiinflammatory, antioxidant, and antiplasmodial activity. The ethanol extract of Gedi leaf
had an analgesic activity which was orally administered in mice and the amount of its
writhing is observed after being induced by heat. The data showed that the analgesic
effect of Gedi leaf ethanol extract at a dose of 60 mg/30 g BB equivalent to a dose of
2000 mg/Kg BB was greater than the positive control dose or tramadol used. Other
research also stated that the petroleum ether and methanol extracts of Gedi leaf showed
flavonoids, steroids, and triterpenoids which had anti-inflammatory and analgesic
activity. Petroleum ether and methanol extract of Gedi leaf at a dose of 400 mg kg -1
showed a maximum reaction time of 14.1 ± 0.21 and a minimum of 6.98 ± 0.29 which
indicates a significant pain threshold.
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