Review artikel: Potensi daun sirih hijau (piper betle l.) dan daun sirih merah (piper crocatum) sebagai antioksidan

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Vol. 2 No. Spesial Issues 3 (2022): Humantech : Jurnal Ilmiah Multidisiplin Indonesia
Published: Mar 30, 2022
Keywords:
Antioxidant, Piper betle Leaf, Piper crocatum Leaf, phytochemical content

Main Article Content

Maria Vianey Uma Kopong
Ni Kadek Warditiani
Universitas Udayana

Abstract

Green Betel (Piper betle.) and Red Betel (Piper crocatum) plants belong to the genus
Piper from the Piperaceae family. It is known that the leaves of the betel plant have
some bioactivity and are used in traditional medicine systems. Many research studies
on the betel plant have reported that it contains important chemical components which
have pharmacological effects, one of which is as an antioxidant. In this review, we
discuss extracts from green and red betel plants as antioxidants and the phytochemical
content contained therein. The review that has been made states that the green and red
betel leaf extracts have antioxidant activity with a widely used method, namely DPPH
(2,2-diphenyl-1-picrylhydrazy) with the results of antioxidant activity tests from the
latest journal showing that the n-hexane fraction is more active as an antioxidant.
Antioxidant (IC50 26.73 mg/L) compared to the diethyl ether fraction (IC50 114.54
mg/L). The phytochemical content of green and red betel leaf extract is positive for
various secondary metabolites such as flavonoids, saponins, terpenoids, steroids,
tannins, alkaloids, and phenolic compounds.

Article Details

How to Cite
Kopong, M. V. U. ., & Ni Kadek Warditiani. (2022). Review artikel: Potensi daun sirih hijau (piper betle l.) dan daun sirih merah (piper crocatum) sebagai antioksidan. Humantech : Jurnal Ilmiah Multidisiplin Indonesia, 2(Spesial Issues 3), 710–729. https://doi.org/10.32670/ht.v2iSpesial Issues 3.1504
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References

Abrahim, N. N., Kanthimathi, M. S., & Abdul-Aziz, A. 2012. Piper betle shows

antioxidant activities, inhibits MCF-7 cell proliferation and increases activities of

catalase and superoxide dismutase. BMC complementary and alternative medicine,

(1), 1-11.

Alam, B., Akter, F., Parvin, N., Pia, R. S., Akter, S., Chowdhury, J., Jahan, K. S., &

Haque, E. 2013. Antioxidant, analgesic and anti-inflammatory activities of the

methanolic extract of Piper betle leaves. Avicenna journal of phytomedicine, 3(2),

Ali, A., Lim, X. Y., Chong, C. H., Mah, S. H., & Chua, B. L. 2018. Ultrasound-assisted

extraction of natural antioxidants from betel leaves (Piper betle): Extraction kinetics

and modeling. Separation Science and Technology, 53(14), 2192-2205.

Annegowda, H. V., Tan, P. Y., Mordi, M. N., Ramanathan, S., Hamdan, M. R., Sulaiman,

M. H., & Mansor, S. M. 2013. TLC–bioautography-guided isolation, HPTLC and

GC–MS-assisted analysis of bioactives of Piper betle leaf extract obtained from

various extraction techniques: in vitro evaluation of phenolic content, antioxidant

and antimicrobial activities. Food Analytical Methods, 6(3), 715-726.

Arambewela, L., Arawwawala, M., & Rajapaksa, D. 2006. Piper betle: a potential natural

antioxidant. International journal of food science & technology, 41, 10-14.

Ariyani, F., Amin, I., & Fardiaz, D. 2015. Ekstrak Air Daun Sirih (Piper betle Linn)

sebagai Antioksidan Alami pada Pengolahan Ikan Patin (Pangasius

hypophthalmus) Asin Kering. Jurnal Pascapanen dan Bioteknologi Kelautan dan

Perikanan, 10(1), 45-59.

Arsad, N. H., Yunus, M. A. C., Zaini, M. A. A., Rahman, Z. A., & Idham, Z. 2016. Effect

of operating conditions of supercritical carbon dioxide on piper betle leave oil yield

and antioxidant activity. International Journal of Applied Chemistry, 12(4), 741-

Dasgupta, N., & De, B. 2004. Antioxidant activity of Piper betle L. leaf extract in vitro.

Food chemistry, 88(2), 219-224.

Guha P. 2006. Betel Leaf: The Neglected Green Gold of India. Journal Hum. Ecol., 19(2):

– 93.

Halliwel, B., Aeschbach, R., Lolinger, J., & Auroma, O. 1995. Toxicology. J Food Chem,

, 60.

Hertiani, T., Pramono, S., & A.M, S. 2000. Uji daya antioksidan senyawa flavonoid daun

(Plantago major L.). Majalah Farmasi Indonesia, 11(4), 234.

Januarti, I. B., Wijayanti, R., Wahyuningsih, S., & Nisa, Z. 2019. Potensi ekstrak

terpurifikasi daun sirih merah (piper crocatum ruiz & pav) sebagai antioksidan dan

antibakteri. J. Pharm Sci, 2, 61.

Manalu, N. Y., & Sinaga, M. S. 2013. Ekstrak daun sirih hijau dan merah sebagai

antioksidan pada minyak kelapa. Jurnal Teknik Kimia USU, 2(1), 37-43.

Middleton, E., Kandaswami, & Theoharides, T. 1998. The effects of plant flavonoids on

mammalian cells: Implications for inflammation, heart disease, and cancer.

Pharmacological Reviews, 52, 673-751.

Mokhtar, N. M., Kanthimathi, M. S., & Aziz, A. A. 2008. Comparisons between the

Antioxidant Activities of the Extracts of Anacardium occidentale and Piper betle.

Malaysian Journal of Biochemistry and Molecular Biology, 16(1), 16-21.

Nur Sazwi, N., Nalina, T., & Rahim, Z. H. A. 2013. Antioxidant and cytoprotective

activities of Piper betle, Areca catechu, Uncaria gambir and betel quid with and

without calcium hydroxide. BMC complementary and alternative medicine, 13(1),

-12.

Peter K. V., Edited. 2015. Woodhead Publishing in Food Science and Technology.

Handbook of Herb and Spices, 2.

Prakash, B., Shukla, R., Singh, P., Kumar, A., Mishra, P. K., & Dubey, N. K. 2010.

Efficacy of chemically characterized Piper betle L. essential oil against fungal and

aflatoxin contamination of some edible commodities and its antioxidant activity.

International Journal of Food Microbiology, 142(1-2), 114-119.

Rahayu, Suparni Setyowati, Teknologi Proses Ekstraksi. http://www.chem-istry.org.

Diakses pada Februari 2022.

Rimando, A. M, Han, B. H, Park J.H, and Cantoria M.C. Studies on the constituents of

Philippine Piper betle leaves. 1986. Arch. Pharm. Res, 9(2): 93-97.

Robinson, T. 1995. Kandungan organik tumbuhan tinggi. Bandung: ITB Press.

Rohyami, Y. 2008. Penentuan kandungan flavonoid dari ekstrak metanol daging buah

mahkota dewa (Phaleria macrocarpa scheff boerl). Jurnal LOGIKA, 5(1), 1-8.

Sarma, C., Rasane, P., Kaur, S., Singh, J., Singh, J., Gat, Y., Garba, U., Kaur, D., &

Dhawan, K. 2018. Antioxidant and antimicrobial potential of selected varieties of

Piper betle L. (Betel leaf). Anais da Academia Brasileira de Ciências, 90: 3871-

Serlahwaty, D., Sugiastuti, S., & Ningrum, R. C. 2011. Aktivitas Antioksidan Ekstrak Air

dan Etanol 70% Daun Sirih Hijau (Piper betle L.) dan Sirih Merah (Piper cf. fragile

Benth.) dengan Metode Perendaman Radikal Bebas DPPH. Jurnal Ilmu

Kefarmasian Indonesia, 9(2), 143-146.

Shalini T, N.K.Verma, D.P Singh, S.K.Chaundhary and A.Rohan, 2012. Piper betle:

phytochemistry, traditional use & pharmacological activity: A review. Intl. Journal

Phar. Res. Develop. 4(4):216:223

Suirta, I. W., & Asih, I. A. R. A. 2019. Suplemen Ekstrak Daun Sirih (Piper betle, Lin)

Dalam Menurunkan Kadar Malondiadelhid Pada Tikus Wistar. Jurnal Kimia

(Journal of Chemistry), 13 (2):185-190.

Suirta, I. W., & Asih, I. A. R. A. 2019. Suplemen Ekstrak Daun Sirih Hijau (Piper betle)

Dalam Menurunkan Kadar Malondialdehid pada Tikus Wistar. JURNAL KIMIA

(JOURNAL OF CHEMISTRY) 13 (2): 185-190.

Sundang, M., Nasir, S. N. S., Sipaut, C. S., & Othman, H. 2012. Antioxidant activity,

phenolic, flavonoid and tannin content of Piper betle and Leucosyke capitella.

Malaysian Journal of Fundamental and Applied Sciences, 8(1): 1-6.

Tiara, P. A., & Farida, Y. 2013. Total Phenolic, Flavonoids Content and Antioxidant

Activity of The Ethanolic Extract of Betel Leaf (Piper betle L.). In The

International Conference in Nanotechnology in Jakarta, 26:1-4.

Tonahi, J. M. M., Nuryanti, S., & Suherman, S. 2014. Antioksidan dari Daun Sirih Merah

(Piper Crocatum). Jurnal Akademika Kimia, 3(3), 158-164.